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Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, 5e
Hartmut Derendorf
,
Stephan Schmidt
Buy Now in Print
Table of Contents
Images
(473)
Table of Contents
Images
(473)
Copyright
About the Authors
Preface
Acknowledgments
Nonproprietary and Brand Names of Drugs in Text and Illustrations
Definitions of Symbols
Section 1: Basic Considerations
p1-2
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Chapter 1: Therapeutic Relevance
p3-18
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Chapter 2: Fundamental Concepts and Terminology
p19-50
Section 2: Exposure and Response after a Single Dose
p51-52
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Chapter 3: Kinetics Following an Intravenous Bolus Dose
p53-76
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Chapter 4: Membranes and Distribution
p77-118
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Chapter 5: Elimination
p119-168
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Chapter 6: Kinetics Following an Extravascular Dose
p169-196
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Chapter 7: Absorption
p197-232
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Chapter 8: Response
p233-264
Section 3: Therapeutic Regimens
p265-266
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Chapter 9: Therapeutic Window
p267-282
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Chapter 10: Constant-Rate Input
p283-318
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Chapter 11: Multiple-Dose Regimens
p319-358
Section 4: Individualization
p359-360
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Chapter 12: Variability
p361-392
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Chapter 13: Genetics
p393-410
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Chapter 14: Age, Weight, and Gender
p411-442
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Chapter 15: Disease
p443-490
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Chapter 16: Nonlinearities
p491-530
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Chapter 17: Drug Interactions
p531-576
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Chapter 18: Initiating and Managing Therapy
p577-610
Section 5: Supplemental Topics
p611-612
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Chapter 19: Distribution Kinetics
p613-656
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Chapter 20: Metabolites and Drug Response
p657-686
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Chapter 21: Protein Drugs
p687-730
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Chapter 22: Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data
p731-758
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Appendix A: Assessment of
AUC
p759-762
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Appendix B: Ionization and the pH Partition Hypothesis
p763-766
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Appendix C: Distribution of Drugs Extensively Bound to Plasma Proteins
p767-774
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Appendix D: Plasma-to-Blood Concentration Ratio
p775-776
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Appendix E: Well-Stirred Model of Hepatic Clearance
p777-780
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Appendix F: Absorption Kinetics
p781-784
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Appendix G: Wagner-Nelson Method
p785-788
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Appendix H: Mean Residence Time
p789-794
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Appendix I: Amount of Drug in Body on Accumulation to Plateau
p795-798
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Appendix J: Introduction to MS Excel Simulations
p799-804
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Appendix K: Answers to Study Problems
p805-902
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