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Clinical Pharmacokinetics: Concepts and Applications, 4e
Malcolm Rowland
,
N. Tozer Thomas
Buy Now in Print
Table of Contents
Images
(475)
Associated
Cases
(15)
Clinical Skills
(43)
Toolkit
(8)
Table of Contents
Images
(475)
Cases
(15)
Clinical Skills
(43)
Toolkit
(8)
Copyright
Preface
Acknowledgement
About the Authors
Nonproprietary and Brand Names of Drugs in Text and Illustrations
Definitions of Symbols
Section I: Basic Considerations
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Chapter 1: Therapeutic Relevance
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Chapter 2: Fundamental Concepts and Terminology
Section II: Exposure and Response After a Single Dose
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Chapter 3: Kinetics Following an Intravenous Bolus Dose
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Chapter 4: Membranes and Distribution
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Chapter 5: Elimination
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Chapter 6: Kinetics Following an Extravascular Dose
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Chapter 7: Absorption
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Chapter 8: Response Following a Single Dose
Section III: Therapeutic Regimens
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Chapter 9: Therapeutic Window
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Chapter 10: Constant-Rate Input
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Chapter 11: Multiple-Dose Regimens
Section IV: Individualization
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Chapter 12: Variability
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Chapter 13: Genetics
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Chapter 14: Age, Weight, and Gender
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Chapter 15: Disease
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Chapter 16: Nonlinearities
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Chapter 17: Drug Interactions
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Chapter 18: Initiating and Managing Therapy
Section V: Individualization
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Chapter 19: Distribution Kinetics
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Chapter 20: Metabolites and Drug Response
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Chapter 21: Protein Drugs
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Chapter 22: Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data
Appendices
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Appendix A: Assessment of
AUC
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Appendix B: Ionization and the pH Partition Hypothesis
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Appendix C: Distribution of Drugs Extensively Bound to Plasma Proteins
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Appendix D: Plasma-to-Blood Concentration Ratio
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Appendix E: Well-Stirred Model of Hepatic Clearance
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Appendix F: Absorption Kinetics
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Appendix G: Wagner-Nelson Method
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Appendix H: Mean Residence Time
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Appendix I: Amount of Drug in Body on Accumulation to Plateau
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Appendix J: Answers to Study Problems
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